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Amino Acids:

GenFX tablets contain purified amino acids, herbal, plant- and animal-derived constituents. Seven of the amino acids in the tablets are essential amino acids. Essential amino acids are not synthesized in the human body and thus are required to be obtained in the diet, from animal- or plant-derived protein sources. Amino acids are the building blocks of proteins, and GenFX provides a total of 12 amino acids to build protein.

Amino acid supplementation may increase body muscle mass and decrease fat deposits (*Dillon et al. 2009). Regulation of nutrient intake and its effects are varied and complex, but it has been shown that an intake of a balanced mixture of amino acids immediately post exercise has anabolic (muscle building) effects (*Biolo et al 1997).

L-lysine, L-arginine, L-ornithine, L-glycine and L-glutamine

It has been seen that oral intake of L-lysine, L-arginine, and L-ornithine (obtained from L-arginine) can allow athletes to gain muscle mass and strength by increasing growth hormone levels (*Zajac et al. 2010, Chromiak and Antonio 2002). Administration of L-lysine or L-arginine by themselves has proven ineffective, but the combination of equal amounts of lysine and arginine can stimulate growth hormone release from the anterior pituitary (*Isidori et al. 1981). Two other amino acids contained in GenFX, L-glycine and L-glutamine, also play a role in inducing GH secretion in middle-aged and elderly subjects (*Arwert et al. 2003).

It should be emphasized that these four amino acids increase natural production of growth hormone, which is mainly released in pulses during deep (REM) sleep. Increased GH levels positively impacts energy, quality of life and lean body mass, decreases fat mass, lowers cholesterol and low density lipoprotein (LDL) levels noticeably within a treatment period of three to six months in GH deficient individuals (*Cuneo et al. 1998, Rudman et al. 1991, Rudman et al. 1990).

L-Pyroglutamate, or L-pyroglutamic acid

L-Pyroglutamate, or L-pyroglutamic acid, an uncommon amino acid contained in GenFX, increases cognition by increasing survival of neuronal cells (*Oono et al. 2009). More memory and cognition enhancing effects were shown in studies to be provided by another amino acid constituent, L-tyrosine. L-tyrosine is the substrate for the production of L-Dopa by tyrosine hydroxylase, allowing survival of dopamine signaling neurons.

PLANT INGREDIENTS

The plant-based components of GenFX, Panax ginseng powder, derived from the Chinese ginseng plant, contains ginsenosides that enhance alertness and neuronal survival (*Chen et al. 2007), and improve circulation. Soy phosphatide complexes (one being lecithin or phosphatidylcholine) improve brain function and memory, and both phosphatides and phytosterols reduce cholesterol and LDL in plasma (decreasing chances for atherosclerosis) by inhibiting cholesterol uptake in the gut (*Cohn et al. 2010, Sanclemente et al. 2009).

ANIMAL BASED COMPONENTS

For the animal-based components of GenFX, extracts from bovine anterior pituitary gland contain trace amounts of adrenocorticotropic (ACTH), thyroid-stimulating (TSH), and growth hormones, prolactin, luteinizing hormone, follicle stimulating hormone, endorphins, and melanocyte stimulating hormone. Similarly, hypothalamic extract contains minute amounts of vasopressin and oxytocin. The peptide hormones in these extracts are likely degraded to amino acids by the gastrointestinal tract, serving as substrates for new protein synthesis, and the steroid hormones not absorbed as functional hormones, but may be used as scaffolds for production of endogenous pituitary and hypothalamic hormones.

WHAT DO ALL THESE INGREDIENTS MEAN TO ME?

The amino acids and plant phosphatides and phytosterols in GenFX can with exercise and a balanced diet help maintain muscle mass and strength, decrease fat deposits, keep cholesterol and LDL levels at low healthy levels in plasma, and help maintain or improve memory and cognition.